Premium
SULFONAMIDE INHIBITION IN MONOCHRYSIS LUTHERP 1
Author(s) -
Ukeles Ravenna
Publication year - 1968
Publication title -
journal of phycology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.85
H-Index - 127
eISSN - 1529-8817
pISSN - 0022-3646
DOI - 10.1111/j.1529-8817.1968.tb04705.x
Subject(s) - sulfanilamide , sulfapyridine , sulfathiazole , biology , sulfonamide , incubation , growth inhibition , sulfisoxazole , incubation period , biochemistry , population , microbiology and biotechnology , antibiotics , stereochemistry , in vitro , chemistry , organic chemistry , tetracycline , demography , sociology
SUMMARY The effect of sulfonamides on growth of the chry‐somonad , Monochrysis lutheri, in a synthetic sea‐water medium was examined over a period of 14 days. The population increased at all sulfonamide concentrations during the first several days of incubation before inhibition became apparent. Inhibitory concentrations ranged from 0.01 to 1.0 mg%. Inhibition luas most pronounced in sulfathiazole; sulfamethazine, sulfapyridine, and sulfanilamide followed in decreasing order. p‐Arninobenzoic acid (0.001‐1.0 mg%) competitively reversed inhibition. Folic acid, thymine, adenine, and vitamin B 12 neither reversed the inhibition nor spared the requirement for p‐aminobenzoic acid. The significance of the inhibition pattern and the potential use of antimetabolites in the marine environment were discussed.