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The translation of the pathological findings described in humans to experimental models of acute motor axonal neuropathy
Author(s) -
Willison Hugh J.
Publication year - 2012
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2012.00423.x
Subject(s) - pathological , acute motor axonal neuropathy , pathogenesis , neuroscience , guillain barre syndrome , medicine , axon , pathology , psychology , immunology
Our mechanistic understanding of the Guillain‐Barre' syndromes (GBS) was greatly enhanced by the human pathological studies of Jack Griffin and colleagues conducted in the mid‐1990s. Subsequently, many of the pathological findings in human GBS were confirmed and extended in animal models. This brief account of GBS pathogenesis focuses on the studies that provided the mechanistic evidence for the role of anti‐ganglioside antibodies and complement in injuring the motor axon in Campylobacter‐associated GBS, thereby supporting the earlier seminal pathological observations.