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Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects
Author(s) -
González Ricardo,
Pedro Teresa,
MartinezHervas Sergio,
Civera Miguel,
Antonia Priego Maria,
Catalá Miguel,
Javier Chaves F.,
Ascaso Juan F.,
Carmena Rafael,
Real Jose T.
Publication year - 2012
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2012.00408.x
Subject(s) - medicine , homocysteine , microalbuminuria , diabetes mellitus , peripheral neuropathy , confounding , peripheral , polyneuropathy , creatinine , type 2 diabetes , plasma homocysteine , prospective cohort study , logistic regression , cohort , gastroenterology , endocrinology
Peripheral polyneuropathy (PN) is a frequent complication of diabetes. However, mechanisms underlying the development of PN are multifactorial and not well understood. Our aim was to examine the association of plasma homocysteine (Hcy) with the prevalence and grade of peripheral PN in patients with type 2 diabetes (T2DM). We studied a cohort of 196 subjects with T2DM classified according to the grade of PN (Neuropathy Disability Score, NDS). Subjects with the highest grade of PN were older and had significantly increased levels of creatinine, microalbuminuria, HbA1c, and plasma Hcy compared to the other two groups. The differences in plasma Hcy values were maintained after correcting for confounding factors. Plasma Hcy, HbA1c, duration of diabetes, and age were predictors of the grade of PN. In conclusion, for each increase of 1 µmol in plasma Hcy there was a 23% increase of the risk of diabetic PN evaluated by NDS. Moreover, the grade of PN was predicted by plasma Hcy and HbA1c values, age and duration of diabetes. Further prospective studies should be conducted to confirm the association of plasma Hcy levels with the grade of PN in subjects with T2DM.