Premium
Bioenergetics in diabetic neuropathy: what we need to know
Author(s) -
Hinder Lucy M.,
Vincent Andrea M.,
Burant Charles F.,
Pennathur Subramaniam,
Feldman Eva L.
Publication year - 2012
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2012.00389.x
Subject(s) - diabetes mellitus , medicine , diabetic neuropathy , oxidative stress , neuroscience , peripheral neuropathy , neurovascular bundle , bioenergetics , bioinformatics , endocrinology , biology , pathology , biochemistry , mitochondrion
Progress in developing treatments for diabetic neuropathy is slowed by our limited understanding of how disturbances in metabolic substrates – glucose and fatty acids – produce nerve injury. In this review, we present the current oxidative stress hypothesis and experimental data that support it. We identify weaknesses in our understanding of diabetes‐disordered metabolism in the neurovascular unit, that is, in critical cell types of the microvascular endothelium, peripheral sensory neurons, and supporting Schwann cells. Greater understanding of peripheral nervous system bioenergetics may provide insight into new drug therapies or improvements in dietary interventions in diabetes or even pre‐diabetes.