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Non‐length dependent small fiber neuropathy. A prospective case series
Author(s) -
Gemignani Franco,
Giovanelli Michela,
Vitetta Francesca,
Santilli Daniele,
Bellanova Maria F.,
Brindani Francesca,
Marbini Adriana
Publication year - 2010
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2010.00252.x
Subject(s) - medicine , rheumatoid arthritis , allodynia , gastroenterology , peripheral neuropathy , diabetes mellitus , dermatology , hyperalgesia , endocrinology , nociception , receptor
We report the features of non‐length dependent small fiber neuropathy (SFN) and compare them to those with distal length‐dependent SFN. In a series of 224 consecutive neuropathy patients, we evaluated 44 patients with SFN diagnosed in the presence of both symptoms and signs. Eleven were classified as non‐length dependent SFN. Disease associations were Sjögren's syndrome (two patients), impaired glucose tolerance, rheumatoid arthritis, hepatitis C virus, Crohn's disease, and idiopathic (five patients). In the 33 patients with distal SFN, the age of onset was significantly older and more had impaired glucose metabolism (16/33). In both groups, pain was mainly characterized as burning, but patients with non‐length dependent SFN more often reported an “itchy” quality and allodynia to light touch.