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Effect of glucocorticoid receptor gene polymorphisms in Guillain‐Barré syndrome
Author(s) -
Dekker Marieke J. H. J.,
Van Den Akker Erica L. T.,
Koper Jan Willem,
Manenschijn Laura,
Geleijns Karin,
Ruts Liselotte,
Van Rijs Wouter,
TioGillen Anne P.,
Van Doorn Pieter A.,
Lamberts Steven W. J.,
Jacobs Bart C.
Publication year - 2009
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2009.00216.x
Subject(s) - haplotype , minor allele frequency , allele , single nucleotide polymorphism , genetics , biology , glucocorticoid receptor , guillain barre syndrome , gene , immunology , genotype
Guillain‐Barré syndrome (GBS) is a postinfectious immune‐mediated polyneuroradiculopathy in which host factors influence disease susceptibility and clinical course. Single‐nucleotide polymorphisms (SNPs) in the glucocorticoid receptor (GR) gene influence the sensitivity to glucocorticoids and are related to both microbial colonization and susceptibility to develop auto‐immune disease. This genetic variation may therefore also influence the chance to develop GBS. In this study, we genotyped 318 GBS patients and 210 control subjects for five known SNPs in the GR gene. We could distinguish six different GR haplotypes of which two carried the Bcl I polymorphism: haplotype 1, which consists of the minor allele of Bcl I in combination with the common variant of TthIII I and haplotype 2, which carries the minor allele of Bcl I as well as the minor allele of TthIII I. The GR haplotypes were not related to susceptibility to develop GBS. Carriers of haplotype 2 had more frequently preceding diarrhea, serum antibodies to GM1 and GD1a, and more severe muscle weakness at entry. Haplotype 1 carriers had a significantly better prognosis. In conclusion, GR haplotypes are not a susceptibility factor for GBS. However, haplotypes carrying the minor allele of the Bcl I polymorphism were related to the phenotype and outcome of GBS.