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Isolated amyloidosis presenting with lumbosacral radiculoplexopathy: description of two cases and pathogenic review
Author(s) -
Ladha Shafeeq S.,
Dyck P. James B.,
Spinner Robert J.,
Perez Domingo G.,
Zeldenrust Steven R.,
Amrami Kimberly K.,
Solomon Alan,
Klein Christopher J.
Publication year - 2006
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2006.00107.x
Subject(s) - plasma cell dyscrasia , amyloidosis , medicine , pathology , lumbosacral joint , dyscrasia , pathogenesis , plasma cell , immunoglobulin light chain , surgery , immunology , bone marrow , antibody
Abstract In this study, we present two cases of infiltrative, localized amyloidosis involving lumbosacral root and plexus, e.g., isolated amyloidomas. Rare and poorly understood amyloidomas may occur in both neurologic and non‐neurologic tissues. The described cases emphasize potential for localized peripheral amyloidomas: (1) potential for associated λ light chain lymphoplasmacytic lymphoma association; (2) e isolated amyloidosis without evidence for systemic plasma cell dyscrasia; (3) features suggestive of potential pathogenesis; and (4) discussion of treatment options including immunotherapy and resection. The limited literature and experience among other cases is described.