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Expression of the antioxidant enzyme peroxiredoxin 5 in the human peripheral nervous system
Author(s) -
Lu Jun Lan,
Vallat JeanMichel,
Pollard John D,
Knoops Bernard,
Ouvrier Robert
Publication year - 2006
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2006.00104.x
Subject(s) - axoplasm , immunogold labelling , microbiology and biotechnology , peroxiredoxin , biology , myelin , peripheral nervous system , wallerian degeneration , nervous system , axon , nervous tissue , axotomy , central nervous system , peroxidase , neuroscience , anatomy , biochemistry , ultrastructure , enzyme , regeneration (biology)
Peroxiredoxins (PRDXs) belong to a family of peroxidases that are highly expressed in mammalian tissues. Comparatively, little is known about their expression in the nervous system. In this study, we examined in human sural nerve, the expression of PRDX5, the most recently defined peroxiredoxin family member. Immunohistochemical staining of paraffin sections showed that PRDX5 expression was mainly localised to the axon and, to a lesser extent, to the Schwann cells. Immunogold labelling electron microscopy further revealed that PRDX5 is widely distributed in multiple cellular compartments, most importantly in mitochondria but also in axoplasm, Schwann cell cytosol, nucleus, and myelin. A progressive decline in PRDX5 expression with advancing age was identified in human nerves at different ages. The wide distribution of PRDX5 in cellular and sub‐cellular structures indicates that it may play important roles in a wide range of tissue components in normal peripheral nerves.