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NORMAL HUMAN PLASMA CONTAINS ANTIBODIES THAT SPECIFICALLY BLOCK NEUROPATHY‐ASSOCIATED HUMAN ANTI‐GM1 IGG‐ANTIBODIES
Author(s) -
Lopez Phh,
Irazoqui Fj,
Nores Ga
Publication year - 2000
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2000.22-33.x
Subject(s) - antibody , immunology , idiotype , medicine , human plasma , multifocal motor neuropathy , immunoglobulin g , monoclonal antibody , chemistry , mismatch negativity , electroencephalography , chromatography , psychiatry
Intravenous immunoglobulin (IVIg) is used in the treatment of a variety of autoimmune diseases. The blocking of disease‐associated antibodies by anti‐idiotype antibodies present in IVIg has been proposed as an action mechanism. Anti‐GM1 antibodies have been implicated in motor neuropathies. Although IVIg is frequently applied for these diseases, the presence in IVIg or in human plasma of anti‐idiotype antibodies that recognize anti‐GM1 antibodies has not been clearly demonstrated. Here we present evidence that normal human plasma contains antibodies that inhibit the binding of anti‐GM1 IgG‐antibodies from neuropathy patients but do not inhibit anti‐GM1 IgG‐antibodies of rabbit origin with the same fine specificity. The significance of these findings in the course of acute and chronic neuropathies is discussed.