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CAMPYLOBACTER JEJUNI LIPOPOLYSACCHARIDES FROM GUILLAIN‐BARRE SYNDROME PATIENTS INDUCE IGG ANTI‐GM1 ANTIBODIES IN RABBITS
Author(s) -
Ang Cw,
Endtz Hp,
Jacobs Bc,
Laman Jd,
De Klerk Ma,
Van Doorn Pa
Publication year - 2000
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/j.1529-8027.2000.22-11.x
Subject(s) - campylobacter jejuni , molecular mimicry , guillain barre syndrome , antibody , ganglioside , microbiology and biotechnology , epitope , immunology , virology , medicine , biology , bacteria , biochemistry , genetics
Lipopolysaccharides (LPS) from Campylobacter jejuni strains isolated from patients with Guillain‐Barre syndrome (GBS) display molecular mimicry with GM1. We immunized rabbits with C. jejuni LPS from GBS‐associated strains containing a GM1‐like epitope. All animals produced high titre anti‐LPS antibodies that were cross‐reactive with GM1. We conclude that C. jejuni strains from GBS patients are able to induce antibodies that cross‐react with gangliosides and LPS. This study further confirms the role of molecular mimicry in the induction of anti‐ganglioside antibodies in GBS patients.