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Management of neutrophilic dermatoses
Author(s) -
Schadt Courtney R.,
Callen Jeffrey P.
Publication year - 2012
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/j.1529-8019.2012.01488.x
Subject(s) - pyoderma gangrenosum , medicine , neutrophilic dermatosis , dermatology , sweet syndrome , infiltration (hvac) , pyoderma , disease , immunology , pathology , physics , thermodynamics
Neutrophilic dermatoses, including S weet's syndrome, pyoderma gangrenosum, and rheumatoid neutrophilic dermatitis, are inflammatory conditions of the skin often associated with underlying systemic disease. These are characterized by the accumulation of neutrophils in the skin. The associated conditions, potential for systemic neutrophilic infiltration, and therapeutic management of these disorders can be similar. S weet's syndrome can often be effectively treated with a brief course of systemic corticosteroids. Pyoderma gangrenosum, however, can be recurrent, and early initiation of a steroid‐sparing agent is prudent. Second‐line treatment for both of these conditions includes medications affecting neutrophil function, in addition to immunosuppressant medications.