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Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus
Author(s) -
Hashimoto Takashi,
Kawakami Tamihiro,
Koga Hiroshi,
Ohyama Bungo,
Hamada Takahiro,
Dainichi Teruki,
Nakama Takekuni,
Yasumoto Shinichiro,
Tsuruta Daisuke,
Ishii Norito
Publication year - 2012
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/j.1529-8019.2012.01469.x
Subject(s) - mizoribine , pemphigus foliaceus , pemphigus vulgaris , medicine , pemphigus , prednisolone , gastroenterology , dermatology , immunology , autoantibody , antibody
We evaluated the effectiveness of mizoribine, a newly developed immunosuppressive agent, as an adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. Eleven pemphigus patients (eight pemphigus vulgaris and three pemphigus foliaceus) received the combination therapy of prednisolone and mizoribine. Complete remission was observed in three of the eight patients with pemphigus vulgaris and in one of the three patients with pemphigus foliaceus. The four patients with complete remission had a rapid clinical response and achieved remission at a median of 11.8 months. Partial remission was achieved in two of the three patients with pemphigus foliaceus. The median time to achieve partial remission was 16.0 months. Six (55.6%) of the 11 patients with pemphigus had complete or partial remission and were able to taper their prednisolone. The cumulative probability of having a complete remission was 64.3% at 19 months of follow‐up using K aplan– M eier analysis. The effectiveness of the additional mizoribine therapy could be attributed to its corticosteroid‐sparing properties as well as its immunosuppressive effects. The serum concentration titer of mizoribine was around 1.0 μg/ mL 2 hours after administration. Patients who were not improved by the additional mizoribine might require a continuously higher dose of mizoribine to achieve effective therapy.