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Treatment of disseminated granuloma annulare with allopurinol: case report
Author(s) -
Mazzatenta Carlo,
Ghilardi Alberto,
Grazzini Marta
Publication year - 2010
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/j.1529-8019.2009.01283.x
Subject(s) - granuloma annulare , medicine , allopurinol , sarcoidosis , dermatology , granuloma , granulomatous disease , disease , dermis , granulomatous inflammation , pathology
Granuloma annulare (GA) is a rare disease characterized by granulomatous inflammation of the dermis. A variant form of the disease, disseminated granuloma annulare (DGA), can be observed in about 15% of affected patients. Localized GA is likely to resolve spontaneously within months or a few years, whereas DGA can persist for decades. Various therapies have been suggested in these cases, but none of them has been demonstrated to be consistently efficacious. Allopurinol has been successfully used in granulomatous diseases such as sarcoidosis or reactions to polymethylmethacrylate spheres; therefore, we decided to evaluate the possible efficacy of this drug in three patients with long‐lasting, therapy‐resistant DGA.