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The use of retinoids in the treatment of photoaging
Author(s) -
Singh Minal,
Griffiths Christopher E. M.
Publication year - 2006
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/j.1529-8019.2006.00087.x
Subject(s) - photoaging , medicine , tazarotene , dermatology , hyperpigmentation , skin aging , isotretinoin , retinoid , tretinoin , clinical trial , randomized controlled trial , acne , pathology , retinoic acid , biochemistry , chemistry , gene
ABSTRACT: Photoaging describes the clinical and histologic consequences of chronic sun exposure, the key features of which – wrinkles and mottled hyperpigmentation – are frequently and erroneously attributed to the aging process. Although a number of surgical procedures can improve the clinical appearance of photoaged skin, the only medical therapy with proved benefit derived from randomized clinical trial evidence is the use of topical retinoids, particularly tretinoin, isotretinoin, and tazarotene. Retinoids are capable not only of repairing photoaged skin at both the clinical and biochemical levels but their use may prevent photoaging. There is in addition emerging evidence that topical retinoids could be beneficial in the treatment of intrinsically aged skin.