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Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology
Author(s) -
Van De Kerkhof Peter C. M.
Publication year - 2006
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/j.1529-8019.2006.00082.x
Subject(s) - acitretin , retinoid , psoriasis , medicine , tazarotene , dermatology , bexarotene , retinoic acid , pharmacology , tretinoin , nuclear receptor , biochemistry , chemistry , transcription factor , gene
Both in the topical and systemic treatment of psoriasis, retinoids are mainstays. In this chapter the history and modes of actions of retinoids are presented. Tazarotene and acitretin are the only retinoids that are available in both topical and systemic formulations. A more extensive description of their pharmacology, modes of action, indications and contraindications, clinical results, and treatment strategies will be presented. Finally, retinoid X receptor ligands and retinoic acid metabolism blocking agents will be introduced as potential future retinoid mimetics in psoriasis.