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Neonatal skin barrier: structure, function, and disorders
Author(s) -
Shwayder Tor,
Akland Tom
Publication year - 2005
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/j.1529-8019.2005.05011.x
Subject(s) - lamellar ichthyosis , staphylococcal scalded skin syndrome , medicine , ichthyosis , dermatology , congenital ichthyosis , epidermolysis bullosa , barrier function , erythroderma , genetics , staphylococcus aureus , biology , bacteria , mathematical optimization , mathematics
The development of the human skin from intrauterine to extrauterine life is a balletic interplay of maturing layers and interlocking structures. We discuss this transition and then branch out to touch on issues of premature infant as well as neonatal skin care. Disruption of the barrier function due to toxins and development errors are expounded upon. Staph scalded skin syndrome, collodion membrane, bullous congenital ichthyosiform erythroderma, autosomal recessive ichthyosis (lamellar and congenital ichthyosiform erythroderma), and harlequin fetus are used as examples of these disruptions. Discussion of therapy with the authors’ experience highlights each disease.