Premium
Long‐term cardiac rhythm and repolarization abnormalities in refractory focal and generalized epilepsy
Author(s) -
Nei Maromi,
Sperling Michael R.,
Mintzer Scott,
Ho Reginald T.
Publication year - 2012
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2012.03561.x
Subject(s) - epilepsy , refractory (planetary science) , medicine , repolarization , implantable loop recorder , cardiology , tonic (physiology) , central nervous system disease , anesthesia , electrophysiology , atrial fibrillation , physics , psychiatry , astrobiology
Summary This prospective study evaluated 19 individuals with refractory focal or generalized epilepsy utilizing an implantable cardiac loop recorder. Recording averaged 15 months (range 12–19 months) in 18 patients and 1.5 months in one patient. A median of 37 seizures per patient (range 3–657) occurred, with 1,477 seizures total. Cardiac arrhythmias and repolarization abnormalities occurred frequently (in 42% of patients) in refractory epilepsy, particularly during generalized tonic–clonic and tonic seizures. Patients with Lennox‐Gastaut syndrome may be at high risk for cardiac abnormalities.