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Supplementary motor cortex involvement in reading epilepsy revealed by magnetic source imaging
Author(s) -
de beeck Marc Op,
Legros Benjamin,
Gaspard Nicolas,
Bourguig Mathieu,
Jurysta Fabrice,
Van Bogaert Patrick,
Goldman Serge,
Jousmäki Veikko,
De Tiège Xavier
Publication year - 2011
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2011.03050.x
Subject(s) - magnetoencephalography , myoclonus , neuroscience , epilepsy , myoclonic jerk , psychology , supplementary motor area , motor cortex , primary motor cortex , audiology , idiopathic generalized epilepsy , movement disorders , electroencephalography , medicine , functional magnetic resonance imaging , pathology , disease , stimulation
Summary Reading epilepsy (RE) is an idiopathic reflex epilepsy syndrome characterized by perioral myoclonic jerks (PMJs) during reading associated with left‐dominant frontotemporal spike‐wave discharges (SWDs). To better understand the pathophysiology of this syndrome, we studied a 45‐year‐old patient using magnetic source imaging (MSI). The patient underwent two whole‐head magnetoencephalography (MEG) recordings (Elekta Neuromag Oy) within 2 months while reading aloud. Forty‐two SWDs associated with PMJs were recorded and averaged with respect to SWDs peak power. Epileptic discharges were then reconstructed using conventional equivalent current dipoles (ECDs) modeling, distributed sources sLORETA modeling, and beamformer approach. These methods identified two brain sources located in the left supplementary motor cortex (SMC) and the left primary sensorimotor face area (PSMFA). The spatiotemporal pattern of the sources was characterized by a cross‐talk between these two brain regions, with an initial source in the left SMC. This MSI investigation suggests that RE‐PMJs are associated with reading‐induced activation of hyperexcitable neurons in the left SMC, followed by secondary propagation to the left PSMFA producing the myoclonus.