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Oculogyric crises secondary to lamotrigine overdosage
Author(s) -
Veerapandiyan Aravindhan,
Gallentine William B.,
Winchester Sara A.,
Baker John,
Kansagra Sujay M.,
Mikati Mohamad A.
Publication year - 2011
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2010.02967.x
Subject(s) - lamotrigine , medicine , anesthesia , pediatrics , psychiatry , epilepsy
Summary We report four patients with no preexisting movement disorders who developed oculogyric crises secondary to lamotrigine toxicity and had resolution of these crises after dose reduction. Episode numbers ranged from 1–20 per day and episode duration from 2 s to several hours. Mean plasma concentration of lamotrigine at the time of oculogyric crisis was 15.5 μg/mL, with a mean dose of 16 mg/kg per day.