Premium
Hyponatremia and risk of seizures: A retrospective cross‐sectional study
Author(s) -
Halawa Imad,
Andersson Tomas,
Tomson Torbjörn
Publication year - 2011
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2010.02939.x
Subject(s) - hyponatremia , odds ratio , medicine , confidence interval , retrospective cohort study , epilepsy , medical record , sodium , pediatrics , anesthesia , psychiatry , chemistry , organic chemistry
Summary This retrospective cross‐sectional study was carried out to study the association between different levels of hyponatremia and the occurrence of epileptic seizures in patients without a prior epilepsy diagnosis. We identified from the hospital database, 363 inpatients of a Swedish County hospital who between March 2003 and August 2006 were found to have serum sodium levels <125 m m . Medical records were reviewed and we identified 11 patients with seizures in conjunction with their hyponatremia. Seizures were the only neurologic manifestation of hyponatremia in patients with serum sodium levels >115 m m . Of 150 patients reviewed with serum sodium levels of 120–124 m m , one had a seizure. Using 120–124 m m as reference, odds ratios (95% confidence interval) for having seizures at serum sodium levels of 115–119 m m was 3.85 (0.40–37.53), 8.43 (0.859–82.85) at 110–114 m m , and 18.06 (1.96–166.86) at <110 m m .