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Depression and epilepsy: A bidirectional relation?
Author(s) -
Kanner Andres M.
Publication year - 2011
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2010.02907.x
Subject(s) - serotonergic , glutamatergic , epilepsy , neuroscience , neurotransmitter , population , depression (economics) , psychology , glutamate receptor , medicine , serotonin , central nervous system , receptor , environmental health , economics , macroeconomics
Summary A bidirectional relation between depressive disorders and epilepsy has been suggested by several population‐based studies and is supported by experimental studies. This article reviews the potential pathogenic mechanisms operant in both disorders that may explain such a relation. These mechanisms include a hyperactive hypothalamic–pituitary–adrenal (HPA) axis and its neuroanatomic and neuropathologic complications, as well as disturbances in serotonergic, noradrenergic, γ‐aminobutyric acid (GABA)ergic and glutamatergic neurotransmitter systems, all of which may be interrelated.