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Role of cortical dysplasia in epileptogenesis following prolonged febrile seizure
Author(s) -
Park KyungIl,
Chu Kon,
Jung KeunHwa,
Kim JinHee,
Kang KyungMuk,
Lee SoonTae,
Park HeeKwon,
Kim Manho,
Lee Sang Kun,
Roh JaeKyu
Publication year - 2010
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2010.02676.x
Subject(s) - epileptogenesis , gliosis , hippocampal sclerosis , hippocampal formation , epilepsy , cortical dysplasia , neuroscience , convulsion , temporal lobe , dentate gyrus , febrile seizure , pathology , medicine , psychology
Summary Purpose: Hippocampal sclerosis, characterized by prominent neuronal loss and reactive gliosis, is the most common pathology in human temporal lobe epilepsy (TLE). Although prolonged febrile convulsion (FC) is a risk factor of TLE, it is not clear whether FC provokes hippocampal sclerosis and subsequent TLE. Given that underlying brain lesions, such as cortical dysplasia (CD), in the immature brain predispose patients to FC, CD may link FC and TLE. However, the role of CD in epileptogenesis after FC is also unclear. Here, we investigated whether inborn CD increases the risk of later epilepsy induced by prolonged FC using a rat model. Methods: Experimental CD was induced by in utero exposure of methylazoxymethanol (MAM). Rat pups from MAM‐treated or control rats were then subjected to prolonged FC. We examined morphologic changes in the hippocampi with respect to neuronal loss, reactive gliosis, and synaptogenesis, and evaluated spontaneous recurrent seizures (SRS) by long‐term video‐EEG (electroencephalography). Results: The MAM+FC group had a significantly lower hippocampal neuronal density in the CA1 and dentate hilus than other control groups. A robust increase in glial cells and synaptic reorganization was also detected in the MAM+FC groups. Furthermore, later SRS occurred in all rats in the MAM+FC group and in 50% and 25% of the rats in the FC‐only and MAM‐only group, respectively. The frequency and total duration of SRS was highest in the MAM+FC group. Discussion: Our results suggest that preexisting CD in the immature brain augments the proepileptogenic effects of prolonged FC, leading to TLE.