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Type 1 diabetes and epilepsy: Efficacy and safety of the ketogenic diet
Author(s) -
Dressler Anastasia,
Reithofer Eva,
TrimmelSchwahofer Petra,
Klebermasz Katrin,
Prayer Daniela,
Kasprian Gregor,
Rami Birgit,
Schober Edith,
Feucht Martha
Publication year - 2010
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2010.02543.x
Subject(s) - ketogenic diet , epilepsy , glycemic , medicine , type 2 diabetes , diabetes mellitus , type 1 diabetes , hemiparesis , pediatrics , hypoglycemia , endocrinology , psychiatry , angiography
Summary Diabetes type 1 seems to be more prevalent in epilepsy, and low‐carbohydrate diets improve glycemic control in diabetes type 2, but data on the use of the classic ketogenic diet (KD) in epilepsy and diabetes are scarce. We present 15 months of follow‐up of a 3 years and 6 months old girl with diabetes type 1 (on the KD), right‐sided hemiparesis, and focal epilepsy due to a malformation of cortical development. Although epileptiform activity on electroencephalography (EEG) persisted (especially during sleep), clinically overt seizures have not been reported since the KD. An improved activity level and significant developmental achievements were noticed. Glycosylated hemoglobin (HbA1c) levels improved, and glycemic control was excellent, without severe side effects. Our experience indicates that diabetes does not preclude the use of the KD.