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A ketogenic diet does not impair rat behavior or long‐term potentiation
Author(s) -
Thio Liu Lin,
Rensing Nicholas,
Maloney Susan,
Wozniak David F.,
Xiong Chengjie,
Yamada Kelvin A.
Publication year - 2010
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2009.02515.x
Subject(s) - long term potentiation , ketogenic diet , perforant path , synaptic plasticity , endocrinology , medicine , neuroscience , psychology , biology , epilepsy , receptor
Summary The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically. We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie‐restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD‐fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired‐pulse modulation (PPM) and long‐term potentiation (LTP) in the medial perforant path in vivo. KD‐fed rats performed similarly to SD‐fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.