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Topiramate overdose: A case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticus
Author(s) -
Brandt Christian,
Elsner Heike,
Füratsch Nora,
Hoppe Matthias,
Nieder Esther,
Rambeck Bernhard,
Ebner Alois,
May Theodor W.
Publication year - 2010
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2009.02395.x
Subject(s) - topiramate , status epilepticus , lorazepam , anesthesia , medicine , epilepsy , anticonvulsant , pediatrics , psychiatry
Summary We report the case of a 21‐year‐old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 μg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication.