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Middle short gyrus of the insula implicated in speech production: Intracerebral electric stimulation of patients with epilepsy
Author(s) -
Afif Afif,
Minotti Lorella,
Kahane Philippe,
Hoffmann Dominique
Publication year - 2010
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2009.02271.x
Subject(s) - stereoelectroencephalography , epilepsy , insular cortex , insula , semiology , stimulation , cortex (anatomy) , medicine , epilepsy surgery , neuroscience , superior temporal gyrus , audiology , psychology , functional magnetic resonance imaging
Summary Purpose: Different lines of evidence have suggested an involvement of the insular cortex in speech production. These have included results from lesion studies, functional imaging techniques, and electrical stimulation of the human insular cortex during invasive evaluation of epileptic patients. Methods: We evaluated 25 patients who had drug refractory focal epilepsy with at least one electrode stereotactically implanted in the insular cortex. Results: Eight responses to insular cortex electrical stimulation were reported by five patients as speech arrest (five responses) and a lowering of voice intensity (three responses). Conclusions: Data from this study implicate the middle short gyrus of the insula in the production of speech and show the importance of intrainsular electrode implantation during invasive pre‐resection evaluation by stereo‐electroencephalography (SEEG) when speech arrest occurs early in seizure semiology.