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Diet, ketones, and neurotrauma
Author(s) -
Prins Mayumi
Publication year - 2008
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2008.01852.x
Subject(s) - traumatic brain injury , neuroprotection , head injury , medicine , incidence (geometry) , disease , intensive care medicine , anesthesia , pediatrics , surgery , psychiatry , physics , optics
SummaryThe annual incidence of traumatic brain injury far exceeds the rates of any other disease in the United States, yet progress toward age‐relevant therapies, attention to patients needs, and research funding have all been minimal. Cerebral metabolism of glucose has been shown to be altered after head injury, and increasing cerebral metabolism of alternative substrates (ketones) has been shown to be neuroprotective in several models of traumatic brain injury. This altered dietary approach may have tremendous therapeutic potential for both the pediatric and adult head‐injured populations.