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The contribution of norepinephrine and orexigenic neuropeptides to the anticonvulsant effect of the ketogenic diet
Author(s) -
Weinshenker David
Publication year - 2008
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2008.01850.x
Subject(s) - anticonvulsant , orexigenic , norepinephrine , ketogenic diet , neuropeptide , medicine , endocrinology , epilepsy , pharmacology , neuropeptide y receptor , dopamine , psychiatry , receptor
SummaryThe ketogenic diet (KD) is a high‐fat, low‐carbohydrate, low‐protein diet used to treat refractory epilepsy. Despite its efficacy and many years of investigation, the mechanism by which the KD exerts its anticonvulsant effect remains controversial and poorly understood. The purpose of this article is to review the available data considering two classes of molecules that may contribute to the anticonvulsant effect of the KD: norepinephrine and the orexigenic neuropeptides galanin and neuropeptide Y.