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Adiponectin and visfatin concentrations in children treated with valproic acid
Author(s) -
Rauchenzauner Markus,
Haberlandt Edda,
SchollBürgi Sabine,
Ernst Barbara,
Hoppichler Fritz,
Karall Daniela,
Ebenbichler Christoph F.,
Rostasy Kevin,
Luef Gerhard
Publication year - 2008
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2007.01460.x
Subject(s) - adiponectin , valproic acid , adipokine , endocrinology , medicine , leptin , insulin resistance , carbohydrate metabolism , overweight , insulin , obesity , epilepsy , psychiatry
SummaryChronic antiepileptic therapy with valproic acid (VPA) is associated with increased body weight and insulin resistance in adults and children. Attempts to determine the underlying pathophysiologic mechanisms have failed. Adipocytokines have recently been defined as a link between glucose and fat metabolism. We herein demonstrate that VPA‐associated overweight is accompanied by lower adiponectin and higher leptin concentrations in children. The absence of any relationship with visfatin concentration does not suggest a role of this novel insulin‐mimetic hormone in VPA‐associated metabolic alterations. Therefore, adiponectin and leptin but not visfatin may be considered as potential regulators of glucose and fat metabolism during VPA‐therapy.