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Is Photosensitive Epilepsy Less Common in Males Due to Variation in X Chromosome Photopigment Genes?
Author(s) -
Taylor Isabella,
Hodgson Bree,
Scheffer Ingrid E.,
Mulley John,
Berkovic Samuel F.,
Dibbens Leanne
Publication year - 2007
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2007.01138.x
Subject(s) - epilepsy , allele , photopigment , x chromosome , biology , genetics , allele frequency , polymorphism (computer science) , gene , neuroscience , retina
Summary: Photosensitive epilepsy is less frequent among males than females. Red is the most epileptogenic color. The X‐linked red pigment gene contains the polymorphism Ser180Ala; the Ser180 allele increases red sensitivity. We hypothesized that the paucity of males with photosensitive epilepsy is explained by the distribution of this sex‐linked allele, and predicted photosensitive males would have a low frequency of this allele. We genotyped 35 males with photosensitive epilepsy and 84 male controls. Allele frequencies did not differ between these groups. The hypothesis was not supported, so alternate reasons for the sex bias in photosensitive epilepsy must be sought.