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Surgical Outcome in Tuberous Sclerosis Complex: A Multicenter Survey
Author(s) -
Madhavan Deepak,
Schaffer Sarah,
Yankovsky Alexei,
Arzimanoglou Alexis,
Renaldo Florence,
Zaroff Charles M.,
LaJoie Josiane,
Weiner Howard L.,
Andermann Eva,
Franz David N.,
Leonard Jennifer,
Connolly Mary,
Cascino Greg D.,
Devinsky Orrin
Publication year - 2007
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2007.01112.x
Subject(s) - tuberous sclerosis , ictal , medicine , epilepsy , retrospective cohort study , epilepsy surgery , multicenter study , pediatrics , surgery , radiology , randomized controlled trial , psychiatry
Summary: Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.