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Status Epilepticus Triggers Caspase‐3 Activation and Necrosis in the Immature Rat Brain
Author(s) -
Niquet Jerome,
Auvin Stéphane,
Archie Mark,
Seo DaeWon,
Allen Suni,
Sankar Raman,
Wasterlain Claude G.
Publication year - 2007
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2007.01102.x
Subject(s) - status epilepticus , neuroscience , medicine , necrosis , epilepsy , pathology , psychology
Summary: The mode and mechanism of neuronal death induced by status epilepticus (SE) in the immature brain have not been fully characterized. In this study, we analyzed the contribution of neuronal necrosis and caspase‐3 activation to CA1 damage following lithium‐pilocarpine SE in P14 rat pups. By electron microscopy, many CA1 neurons displayed evidence of early necrosis 6 hours following SE, and the full ultrastructural features of necrosis at 24–72 hours. Caspase‐3 was activated in injured (acidophilic) neurons 24 hours following SE, raising the possibility that they died by caspase‐dependent “programmed” necrosis.