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Postoperative Recovery of Hippocampal Contralateral Diffusivity in Medial Temporal Lobe Epilepsy
Author(s) -
Thivard Lionel,
Tanguy MarieLaure,
Adam Claude,
Clémenceau Stéphane,
Dezamis Edouard,
Lehéricy Stéphane,
Dormont Didier,
Chiras Jacques,
Baulac Michel,
Dupont Sophie
Publication year - 2007
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2006.00968.x
Subject(s) - hippocampal sclerosis , ictal , hippocampus , epilepsy surgery , temporal lobe , epilepsy , hippocampal formation , diffusion mri , mesial temporal lobe epilepsy , anesthesia , medicine , psychology , neuroscience , magnetic resonance imaging , radiology
Summary: Purpose: To search for a recovery after surgery of mean diffusivity (MD) values in the contralateral nonsclerotic hippocampus of patients with medial temporal lobe epilepsy (MTLE) and hippocampal sclerosis (HS). Methods: Twenty‐four MTLE patients (12 right‐sided and 12 left‐sided MTLE) and 36 healthy volunteers were investigated using diffusion tensor imaging. A region‐of‐interest approach was used to measure pre‐ and postoperative interictal hippocampal MD values in patients. Results: Diffusion abnormalities in contralateral nonsclerotic hippocampus recovered after surgery (p < 0.0001). A subgroup of 14 patients exhibited a clear increase in MD values whereas the remaining 10 patients were stable. No significant difference was found between the two subgroups for each of the electroclinical data studied including early postoperative outcome, all patients being either seizure free or with rare persistent auras. Conclusions: This finding suggests that diffusion abnormalities in contralateral hippocampus may represent a functional mechanism linked to the active epileptic process.