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EEG‐ f MRI in Children with Pharmacoresistant Focal Epilepsy
Author(s) -
De Tiège Xavier,
Laufs Helmut,
Boyd Stewart G.,
Harkness William,
Allen Philip J.,
Clark Chris A.,
Connelly Alan,
Cross J. Helen
Publication year - 2007
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2006.00951.x
Subject(s) - electroencephalography , epilepsy , magnetic resonance imaging , eeg fmri , medicine , neuroscience , psychology , functional magnetic resonance imaging , focus (optics) , radiology , physics , optics
Summary: Purpose: To evaluate the usefulness of EEG‐combined functional magnetic resonance imaging (EEG‐ f MRI) to localize epileptogenic sources. Methods: Six children (age 8–15 years) with lesional or nonlesional pharmacoresistant focal epilepsy were studied. Results: We found significant activations in four children, activation and deactivation in one child, and widespread deactivation in another. In four children, activations colocalized with the presumed location of the epileptic focus, one of which was confirmed by intracranial EEG. Conclusions: EEG‐ f MRI is a promising tool to noninvasively localize epileptogenic regions in children with pharmacoresistant focal epilepsy.