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Mesial Temporal Inhibition in a Patient with Deep Brain Stimulation of the Anterior Thalamus for Epilepsy
Author(s) -
Zumsteg Dominik,
Lozano Andres M.,
Wennberg Richard A.
Publication year - 2006
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2006.00824.x
Subject(s) - thalamus , deep brain stimulation , stimulation , epilepsy , neuroscience , hippocampal formation , thalamic stimulator , stimulus (psychology) , electrophysiology , electroencephalography , psychology , medicine , parkinson's disease , disease , psychotherapist
Summary: We investigated the electrophysiological effects of high‐frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ITREL II stimulation device led to a significant decrease of cross power spectral density and a nonsignificant decrease of coherence in ipsilateral hippocampal structures. No such effect was found in lateral temporal or contralateral sites. The hippocampal inhibition was clearly related to the voltage (≥7 V) and frequency (≥70 Hz) of the thalamic stimulus and occurred with a delay of approximately 60 s after stimulus onset.