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Retinal Nerve Fiber Layer and Macular Thickness in Adolescents with Epilepsy Treated with Valproate and Carbamazepine
Author(s) -
Lobefalo Lucio,
Rapinese Marcello,
Altobelli Emma,
Di Mascio Raffaella,
Lattanzi Daniela,
Gallenga Pier Enrico,
Chiarelli Francesco,
Verrotti Alberto
Publication year - 2006
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2006.00505.x
Subject(s) - carbamazepine , nerve fiber layer , epilepsy , retinal , medicine , anticonvulsant , ophthalmology , valproic acid , neuroscience , psychology , psychiatry
Summary: Purpose: To evaluate retinal nerve retinal nerve fiber layer (RNFL) and macular thickness by using optical coherence tomography (OCT) in epileptic adolescents before and during monotherapy with valproic acid (VPA) and carbamazepine (CBZ). Methods: We examined prospectively 45 epilepsy patients with partial and generalized epilepsy. The patients were evaluated before the beginning of therapy and after 1 year of VPA or CBZ monotherapy. Forty‐five untreated healthy controls were evaluated at baseline and after 1 year. Results: At the beginning of the study, the two groups of patients showed RNFL and macular thickness measurements similar to control values. At the end of the follow‐up, the data of the three groups were similar to baseline, showing no significant differences in the evaluated parameters. Conclusions: The present study demonstrates that no modification of RNFL and macular thickness parameters is found after 1 year of treatment with VPA and CBZ monotherapy.