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Beta and Gamma Range EEG Power‐Spectrum Correlation with Spiking Discharges in DBA/2J Mice Absence Model: Role of GABA B Receptors
Author(s) -
Marrosu Francesco,
Santoni Federico,
Fà Mauro,
Puligheddu Monica,
Barberini Luigi,
Genugu Fabrizio,
Frau Roberto,
Manunta Mario,
Mereu Giampaolo
Publication year - 2006
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2006.00456.x
Subject(s) - baclofen , antagonist , beta (programming language) , alpha (finance) , epilepsy , electroencephalography , gamma aminobutyric acid , agonist , pharmacology , chemistry , electrophysiology , neuroscience , receptor , endocrinology , medicine , physics , psychology , developmental psychology , construct validity , computer science , programming language , psychometrics
Summary: Purpose: To describe the correlations between spiking pattern and EEG power spectrum frequency in DBA/2J mice, a model for murine absence seizures, after γ‐aminobutyric acid (GABA) B modulation. Methods: The animals were first tested with the GABA B agonist l ‐baclofen followed by the GABA B antagonist SCH 50911. Moreover, digital EEGs recorded under experimental conditions were processed at baseline and 10 and 20 min after l ‐baclofen injection. This procedure was followed by injection of the GABA B antagonist SCH50911 and by an additional EEG evaluation at 10 and 20 min from drug administration. The power spectra analysis of signals was obtained for delta (0.5–3 Hz), theta (3.5–7.5 Hz), alpha (8–12 Hz), beta (13–20 Hz), and gamma (21–50 Hz) frequencies. Results: The spiking pattern and power spectrum of beta activity was increased by ≤80% after administration of 5 mg/kg l ‐baclofen, whereas gamma power frequency decreased to the same extent. After administration of 50 mg/kg SCH 50911, spiking activity and beta power frequencies were markedly reduced (>80%), whereas gamma power increased (correlation, 0.92; p < 0.001). The remaining frequency bands were unaffected. Conclusions: This study confirms the potential of GABA B antagonists in contrasting seizure absence in rodent models and suggests the application of drugs with a similar mechanism in humans. In addition, because GABA B antagonists not only contrast seizure in rodent models of absence but also improve “cognitive” performance, it could be hypothesized that gamma increase, correlated with optimized cortical binding during coherent percepts, may produce potential cognition‐enhancing effects.