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Quantitative MRI Biomarkers of Cognitive Morbidity in Temporal Lobe Epilepsy
Author(s) -
Oyegbile Tayo O.,
Bhattacharya Abhik,
Seidenberg Michael,
Hermann Bruce P.
Publication year - 2006
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2006.00380.x
Subject(s) - epilepsy , temporal lobe , neuropsychology , magnetic resonance imaging , atrophy , white matter , abnormality , medicine , brain size , neuropsychological assessment , cerebrospinal fluid , cognition , psychology , neuroimaging , frontal lobe , pathology , neuroscience , radiology , psychiatry
Summary: Purpose: To determine the relation between neuropsychological morbidity, quantitative magnetic resonance imaging (MRI) measures of whole brain structure, and clinical seizure factors reflecting epilepsy cause, course, and treatment. Methods: Quantitative MRI measurements of total (whole brain) cerebrospinal fluid (CSF) and gray‐ and white‐matter volumes and clinical seizure features were examined in relation to summary indices of cognitive morbidity in 96 patients with temporal lobe epilepsy. MRI volumes were adjusted for intracranial volume (ICV), and cognitive scores were adjusted for age, education, and gender, based on a sample of 82 healthy controls. Results: Whole‐brain volumes (gray, white, and CSF) were abnormal in chronic temporal lobe epilepsy patients compared with controls and were related significantly to neuropsychological morbidity, especially total CSF. Statistical modeling demonstrated that markers of total atrophy (CSF) was the primary mediator of the relation between clinical seizure variables and neuropsychological morbidity. Conclusions: Quantitative measurements of overall brain abnormality (atrophy) in temporal lobe epilepsy are clinically meaningful markers that are associated with increased cognitive morbidity. These biomarkers appear to mediate the adverse effects of some clinical seizure variables on cognition.