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Epileptogenesis due to Peripheral Injury as a Cause of Focal Epilepsy
Author(s) -
Spiller Allison E.,
Guberman Alan,
Bartolomei Fabrice,
Zifkin Benjamin,
Andermann Frederick
Publication year - 2005
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2005.59504.x
Subject(s) - epileptogenesis , epilepsy , medicine , peripheral , clinical neurology , neuroscience , psychology
Summary: Purpose: To report three patients in whom focal epilepsy developed shortly after painful soft tissue injuries to their hands. Methods: Case reports. Results: The attacks started in the injured hand. No evidence was found of an underlying brain lesion by history or from imaging studies. Conclusions: These cases suggest the possibility that the injuries led to a plastic change in the sensory/motor cortex, leading to increased excitability and ultimately to seizures. This suggests that epileptogenesis can occur in response to painful peripheral stimuli in some individuals.