Premium
Self‐Sustaining Status Epilepticus: A Condition Maintained by Potentiation of Glutamate Receptors and by Plastic Changes in Substance P and Other Peptide Neuromodulators
Author(s) -
Wasterlain Claude G.,
Liu Hantao,
Mazarati Andrey M.,
Baldwin Roger A.,
Shirasaka Yukiyoshi,
Katsumori Hiroshi,
Thompson Kerry W.,
Sankar Raman,
Vasconselos Anne Pereira,
Nehlig Astrid
Publication year - 2000
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.2000.tb01572.x
Subject(s) - kainate receptor , perforant path , status epilepticus , nmda receptor , long term potentiation , stimulation , glutamate receptor , hippocampal formation , epilepsy , kainic acid , neuroscience , chemistry , medicine , receptor , endocrinology , pharmacology , ampa receptor , biology
Summary: We describe a model of self‐sustaining status epilepticus (SSSE) induced by stimulation of the perforant path in free‐running rats. In this model, seizures can be transiently suppressed by intrahippocampal injection of a blocker of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid/kainate synapses but return in the absence of further stimulation when the drug ceases to act. However, seizures are irreversibly abolished by blockers of N ‐methyl‐ d ‐aspartate receptors given locally or systemically. SSSE is enhanced by substance P and its agonists and blocked by its antagonists. SSSE induces novel expression of substance P‐like immunoreactivity in hippocampal principal cells. These changes and those in other limbic peptides may contribute to the maintenance of SSSE and to the modulation of hippocampal excitability during epileptic seizures.