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Morphological Plasticity in an Infant Monkey Model of Temporal Lobe Epilepsy
Author(s) -
Wenzel H. Jürgen,
Born Donald E.,
Dubach Mark F.,
Gunderson Virginia M.,
Maravilla Kenneth R.,
Robbins Carol A.,
Szot Partrizia,
Zierath Danielle,
Schwartzkroin Philip A.
Publication year - 2000
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.2000.tb01560.x
Subject(s) - epilepsy , neuroscience , hippocampal formation , temporal lobe , gliosis , status epilepticus , hippocampus , entorhinal cortex , epileptogenesis , psychology , granule cell , neocortex , bicuculline , atrophy , medicine , pathology , dentate gyrus , gabaa receptor , receptor
Summary:Purpose/Methods : Seizures in early life are thought to contribute to the development of human temporal lobe epilepsy. To examine the consequences of early seizures, we elicited status epilepticus in immature, 5.5‐ to 7.0‐month‐old pigtailed macaques by unilateral microinfusion of bicuculline methiodide into the entorhinal cortex. Results : This report focuses on neuropathological changes in the hippocampus. Bicuculline infusion consistently elicited limbic‐like seizures with prolonged, relatively localized electrographic activity. Magnetic resonance imaging revealed enhanced signal intensity in the ipsilateral hippocampus after seizures; in some cases, there was also progressive hippocampal atrophy. Histological changes were variable; in two of five monkeys, there was significant hippocampal neuron loss, gliosis, granule cell dispersion, and mossy fiber reorganization. Conclusions : The histopathological findings and associated magnetic resonance imaging abnormalities after bicuculline‐induced status epilepticus in infant monkeys mimic common aspects of human temporal lobe epilepsy.