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Changes in Benzodiazepine Binding in a Subkindling Situation
Author(s) -
Rössler AnneSophie,
Launay JeanMarie,
Venault Patrice,
Dodd Robert H.,
Chapouthier Georges
Publication year - 2000
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.2000.tb00224.x
Subject(s) - flumazenil , inverse agonist , kindling , benzodiazepine , agonist , gabaa receptor , butyric acid , pharmacology , receptor , chemistry , endocrinology , medicine , psychology , epilepsy , neuroscience , biochemistry
Summary:Purpose : A low dose of the benzodiazepine receptor inverse agonist methyl β‐carboline‐3‐carboxylate (β‐CCM) (1 mg/kg) was used to assess [ 3 H]‐flumazenil binding in a subkindling situation in Swiss mice. Methods : The brains were removed, and benzodiazepine receptor binding was studied every second day over 14 days of administration. Results : With each successive trial, B max values showed a steady and significant decrease, whereas K d values showed a steady and significant increase. Behavioral data showed that at this low dose, actual kindling (seizuring) was not reached at the behavioral level. Conclusions : The findings suggest that decreased γ‐amino‐butyric acid (GABA) inhibition may occur even if behavioral effects of kindling are not observed.