Premium
Bilateral Periventricular and Subcortical Heterotopia in a Man with Refractory Epilepsy
Author(s) -
Sisodiya S. M.,
Free S. L.,
Duncan J. S.,
Stevens J. M.
Publication year - 2000
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.2000.tb00167.x
Subject(s) - heterotopia (medicine) , epilepsy , magnetic resonance imaging , psychology , partial seizures , medicine , neuroscience , pathology , radiology
Summary:Purpose : To report a novel malformation in a male subject with refractory partial seizures. Methods : Magnetic resonance imaging (MRI) and data reformatting in a subject referred for management of partial seizures. Results : The patient had four distinct partial seizure types, without learning disability. MRI demonstrated the novel association of bilateral laminar subcortical heterotopia, bilateral temporal periventricular heterotopia, and hippocampal malformation. Conclusions : This previously unreported complex bilateral neocortical and archicortical malformation in a male patient cannot be explained by known genetic causes of heterotopia, raising the possibility of a novel gene involved in brain formation.