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Cortical Dysplasia with Ossification
Author(s) -
Maehara Taketoshi,
Arai Nobutaka,
Shimizu Hiroyuki,
Yagishita Akira,
Oda Masaya
Publication year - 2000
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.2000.tb00127.x
Subject(s) - cortical dysplasia , medicine , ossification , dysplasia , neuroscience , anatomy , pathology , psychology , radiology , magnetic resonance imaging
Summary: We present the first case of cortical dysplasia with extensive intracerebral ossification. An eight‐year‐old epilepsy patient with a calcified lesion was successfully treated by surgical intervention. Pathological examination revealed a number of bizarre dysplastic cells in the whole lesion, which consisted of an epileptogenic cerebral cortex and a nonepileptogenic hamartomatous lesion with adipose tissue, vascular tissue, calcification, and ossification. The patient was diagnosed as having cortical dysplasia with ossification. Our findings support the notion that cortical dysplasia has a multipotentiality of cellular differentiation, including various hamartomatous tissues. We suggest that cortical dysplasia should be considered as a potential cause for epileptogenicity of a hamartomatous lesion even when magnetic resonance imaging (MRI) fails to disclose cortical dysplasia.