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Effects of Pregnancy on the Pharmacokinetics of Lamotrigine in Dogs
Author(s) -
Matar K. M.,
Nicholls P. J.,
Tekle A.,
Bawazir S. A.,
AlHassan M. I.
Publication year - 1999
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1999.tb02005.x
Subject(s) - pharmacokinetics , lamotrigine , cmax , pregnancy , glucuronidation , medicine , volume of distribution , gestation , pharmacology , anesthesia , chemistry , epilepsy , biology , biochemistry , psychiatry , genetics , enzyme , microsome
Summary:Purpose : This study was designed to evaluate the effects of pregnancy on the kinetics of lamotrigine (LTG). Methods : Five pregnant dogs were given a daily dose of LTG (100 mg) for a period of 1 week. Two months after parturition, the same subjects were given the LTG dose (100 mg) over the same period. On both occasions, plasma LTG concentrations were determined by a sensitive, high‐performance liquid chromatographic (HPLC) method, over a 30‐h period after the last dose. Results : The mean maximum plasma concentration (C max ), volume of distribution (V d /F), and oral body clearance (Cl/F) for LTG (± SD) during pregnancy were 7.63 ± 2.46 μg/ml 1.74 ± 0.29 L/kg, and 0.19 ± 0.04 L/h/kg, respectively. After pregnancy, the same variables were 6.12 ± 2.24 μg/ml, 2.36 ± 1.10 L/kg, and 0.30 ± 0.13 L/h/kg, respectively. None of these pharmacokinetic parameters was found to be significantly different between the two groups. Conclusions : The apparent lack of change in the relevant pharmacokinetic parameters of LTG during pregnancy may indicate that pregnancy has little or no effect on glucuronidation; the principal pathway for the drug's elimination.