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Quantitative EEG Analyses and Surgical Outcome After Corpus Callosotomy
Author(s) -
Matsuzaka Tetsuo,
Ono Kenji,
Baba Hiroshi,
Matsuo Mitsuhiro,
Tanaka Shigeki,
Kamimura Naohisa,
Tsuji Yoshiro
Publication year - 1999
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1999.tb00857.x
Subject(s) - corpus callosotomy , electroencephalography , corpus callosum , psychology , medicine , quantitative electroencephalography , audiology , epilepsy surgery , neuroscience
Summary:Purpose: To clarify the relation between quantitative electroencephalogram (EEG) findings and outcome following corpus callosotomy (CC). Methods : The degree of bilateral synchrony and morphologic similarity of spike‐wave discharges was analyzed by using a cross‐correlation analysis and the measurements of amplitude differences between bilateral homologous regions in 22 patients who underwent anterior CCs for intractable symptomatic generalized epilepsies (SGE; 17 patients) and frontal lobe epilepsy (five patients). Results: Interictal generalized synchronous spike‐wave (GSSW) bursts in the SGE patients were disrupted and changed to unilateral spike‐waves (USWs) in 11 patients and to bilaterally independent spike‐waves (BISWs) in six. The USW group had better surgical outcome than the BISW group. Preoperatively, the USW group had significantly lower interhemispheric synchrony (IS) and fewer regional changes in the side leading in time and the side dominant for amplitude, suggesting unilaterally predominant epileptogenesis that triggered the secondary bilateral synchrony. Postoperatively, the BISW group had a more marked reduction in IS because of independent discharges from bilateral epileptogenic areas, and the USW group had a greater amplitude difference because of unilateralized spike‐waves. In addition, an excellent surgical outcome was related to (a) the preoperative degree of the morphologic similarity of the bilateral spike‐waves (only a small variation during a burst of spike‐waves) and the few instances of regional changes in the side leading in time and in the side dominant for amplitude; and (b) to large postoperative amplitude differences. Conclusion: Preoperative quantitative EEG analyses enabled us to predict the underlying conditions of epileptogenesis and the surgical outcomes in patients undergoing CC.