Premium
Estimation of Topiramate in Subdural Cerebrospinal Fluid, Subcutaneous Extracellular Fluid, and Plasma: A Single Case Microdialysis Study
Author(s) -
Lindberger Martin,
Tomson Torbjörn,
Öhman Inger,
Wallstedt Lars,
Ståhle Lars
Publication year - 1999
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1999.tb00783.x
Subject(s) - microdialysis , cerebrospinal fluid , extracellular fluid , topiramate , chemistry , anesthesia , medicine , extracellular , epilepsy , biochemistry , psychiatry
Summary:Purpose: To estimate topiramate (TPM) concentrations in subdural cerebrospinal fluid (CSF), subcutaneous extracellular fluid (ECF), and plasma and to study the correlation of TPM concentrations in these three different compartments. Methods: In this single case study of a patient with drug‐resistant partial epilepsy undergoing presurgical evaluation with subdural EEG monitoring, we used microdialysis to estimate concentrations of unbound TPM in CSF of the subdural space and ECF of abdominal subcutaneous tissue. Blood samples were drawn for estimation of TPM concentrations in plasma. Results: The correlation between unbound TPM concentrations in subdural CSF and abdominal subcutaneous ECF was good. The mean ratio of ECF/CSF TPM concentration was 0.93 (SD ± 0.03) and the correlation coefficient was 0.98. The mean ratio of ECF/total plasma TPM was 0.75 (SD ± 0.06), and the correlation coefficient was 0.99. The mean ratio of CSF/total plasma TPM was 0.81 (SD ± 0.06), and the correlation coefficient was 0.97. Conclusions: Assuming a protein binding of TPM of −13%, it is concluded that, based on nine microdialysis samples from a single subject, TPM levels in the CSF at the cortical surface are approximately the same as the unbound plasma levels. Additional patients should be studied to confirm the results.