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Ketosis and Epilepsy: 31 P Spectroscopic Imaging at 4.1 T
Author(s) -
Pan J. W.,
Bebin E. M.,
Chu W. J.,
Hetherington H. P.
Publication year - 1999
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1999.tb00766.x
Subject(s) - ketogenic diet , phosphocreatine , ketosis , ictal , epilepsy , medicine , endocrinology , chemistry , energy metabolism , psychiatry , diabetes mellitus
Summary:Purpose: To determine whether changes in the high‐energy phosphates occur with use of the ketogenic diet in patients with intractable epilepsy. Methods:31 P magnetic resonance spectroscopic imaging studies were performed at 4.1 T in seven patients with intractable epilepsy (four Lennox‐Gastaut syndrome, one absence, one primary generalized tonic‐clonic, and one partial complex) before and after institution of the ketogenic diet. Coronal 1 H anatomic imaging also was performed to provide correlation to the 31 P data. Results: Taking the patients as a group, the ratio of phosphocreatine (PC)/γ‐adenosine triphosphate (ATP) measured at baseline (regular diet) compared with that measured after the ketogenic diet showed a small but significant increase from 0.61 ± 0.08 to 0.69 ± 0.08 (p < 0.05). Comparing the ratio of PCr inorganic phosphorus (P i ) measured at baseline with the postketogenic diet, there was a significant increase from 2.45 ± 0.27 to 2.99 ± 0.44 (p < 0.05). Conclusions: As a group, improvement of energy metabolism occurs with use of the ketogenic diet. This is in agreement with the chronic ketosis studies performed earlier in rodents.