Premium
Surgical Treatment of a Case of Early Infantile Epileptic Encephalopathy with Suppression‐Bursts Associated with Focal Cortical Dysplasia
Author(s) -
Komaki Hirofumi,
Sugai Kenji,
Sasaki Masayuki,
Hashimoto Toshiaki,
Arai Nobutaka,
Takada Eiko,
Maehara Taketoshi,
Shimizu Hiroyuki
Publication year - 1999
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1999.tb00719.x
Subject(s) - cortical dysplasia , medicine , ictal , epileptic spasms , magnetic resonance imaging , epilepsy , dysplasia , electroencephalography , encephalopathy , psychomotor learning , pediatrics , surgery , anesthesia , pathology , radiology , cognition , psychiatry
Summary: We report a surgically treated case of early infantile epileptic encephalopathy (EIEE) with supression‐bursts associated with focal cortical dysplasia. Tonic‐clonic seizures followed by a series of spasms occurred about a hundred times a day at a few days of age. Interictal electroencephalogram (EEG) revealed a suppression‐burst pattern that was predominant in the left hemisphere. Magnetic resonance imaging (MRI) suggested focal cortical dysplasia in the left prefrontal area. Combination therapies with antiepileptic treatments showed only partial efficacy. The patient underwent lesionectomy at age 4 months, after which he gradually showed psychomotor development and a decrease of spasms to 0‐2 series daily. In cases of EIEE with focal cortical dysplasia, surgical treatment may have beneficial effects on both psychomotor development and seizure control.