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Carbamazepine Intoxication with Negative Myoclonus After the Addition of Clobazam
Author(s) -
Genton Pierre,
Nguyen Vi Huong,
Mesdjian Edouard
Publication year - 1998
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1157.1998.tb01299.x
Subject(s) - clobazam , carbamazepine , topiramate , myoclonus , anticonvulsant , medicine , anesthesia , regimen , pharmacology , lamotrigine , epilepsy , psychiatry
Summary: We report a case a carbamazepine (CBZ) intoxication with negative myoclonus that occurred 4 weeks after dobazam (CLB) had been added to a stable regimen of CBZ and topiramate (TPM). Both CBZ and CBZ‐epoxide (CBZ‐E) blood levels were elevated, and the symptoms resolved quickly when CBZ dosage was reduced and CLB discontinued. CLB was reintroduced a year later with the patient's consent, and the time course of the interaction was studied: CBZ and CBZ‐E levels increased slowly over 12 days. The interaction is thus probably related to the progressive increase in Nor‐CLB.